Longitudinal validity of PET ‐based staging of regional amyloid deposition
نویسندگان
چکیده
منابع مشابه
In vivo staging of regional amyloid deposition
OBJECTIVES To estimate a regional progression pattern of amyloid deposition from cross-sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging of an individual's amyloid pathology. METHODS Multiregional analysis of florbetapir (18F-AV45)-PET data was used to determine individual amyloid distribution profiles in a sample of 667 participants from the Alzheimer's Dise...
متن کاملTau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition
INTRODUCTION Tau-positron emission tomography (PET) imaging with AV1451 is sensitive to Alzheimer disease (AD)-related tau deposition in the brain. We (1) examined regional variation of average tau-PET standardized uptake value ratios (SUVRs) in a young normal population (30-49 years) and corrected for the regional variability and (2) tested if the standardized values (z-scores) scaled appropri...
متن کاملAmyloid deposition, hypometabolism, and longitudinal cognitive decline.
OBJECTIVE Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) population, we examined (1) cross-sectional relationships between amyloid deposition, hypometabolism, and cognition, and (2) associations between amyloid and hypometabolism measurements and longitudinal cognitive measurements. METHODS We examined associations between mean cortical florbetapir uptake, mean (18) F-...
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BACKGROUND High levels of β-amyloid (Aβ) characterize Alzheimer disease. OBJECTIVE To investigate whether longitudinal changes in Aβ deposition can be detected in vivo in older adults without dementia (hereafter referred to as nondemented). DESIGN Prospective study. SETTING Community-dwelling older adults. PARTICIPANTS Twenty-four nondemented participants (4 with a baseline Clinical Dem...
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Amyloid-β deposition in Alzheimer's disease is thought to start while individuals are still cognitively unimpaired and it is hypothesized that after an early phase of fast accumulation, a plateau is reached by the time of cognitive decline. However, few longitudinal Pittsburgh compound B-positron emission tomography studies have tested this hypothesis, and with conflicting results. The purpose ...
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ژورنال
عنوان ژورنال: Human Brain Mapping
سال: 2020
ISSN: 1065-9471,1097-0193
DOI: 10.1002/hbm.25121